I've tried this on four UEFI devices now with a bunch of Linux ISOs and the generic official Windows 10 ISO.
UEFI will boot EFI files regardless of the boot sector and partitoning. Just extract the ISO (copy it's contents) into the root directory of a blank USB (FAT32) and it will be available to boot.
You can even have multiple ISOs in separate folders and simply swap what you have in the root directory. (This is just moving files already on the USB (not copying them) and takes a few seconds.) My USB had five distro's on it.
The only variable is the secure boot settings. (And obviously not having it on legacy settings if there is that choice.)
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