On XBMC... it will depend on which version you are using whether or not an advancedsettings.xml is needed or not. On mine... justXBMC, SPMC and the alpha Gotham builds didn't require it for hardware decoding... the standard Frodo builds ( that weren't a hacked fork ) did though...
A wired mouse... shouldn't interfere with WiFi connectivity... A wireless mouse ( and/or keyboard ) can though ( bluetooth or RF )... for the wireless ones, I recommend a USB extension cable to get the wireless receiver away from the WiFi antenna's.
Other things that can affect wireless connectivity... 2.4Ghz cordless phones, cameras and similar devices using the 2.4Ghz frequency if they are placed too close to either your device or wireless router. As odd as it may sound... actually placing the device and the wireless router too close together can also affect the connection so make certain to have at least 5-10 foot of distance between them but of course not too far apart either. If they are too close together, it distorts the signal sort of like when you turn up your stereo too loud for the speakers to handle.
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